SAN DIEGO–(BUSINESS WIRE)–January 8, 2018–

In a collaboration that would result in a brand new class of medication to exchange opioids and assist combat the nationwide opioid epidemic, Renew Biopharma right this moment introduced it’s collaborating with Ken Mackie from the Indiana University (Bloomington) Gill Center for Biomolecular Science to assist display and develop human therapeutics utilizing Renew’s pure and novel cannabinoid molecules in a pre-clinical drug discovery program.

The program will discover – for the primary time – the efficacy of quite a few molecules for drugs throughout all kinds of potential indications, from ache administration to epilepsy and numerous neurodegenerative ailments.

Many of the Renew-produced molecules haven’t been explored earlier than as a result of they happen in very restricted portions within the Cannabis plant. Instead of utilizing Cannabis vegetation, Renew’s microbial biosynthetic platform can produce these pure and novel cannabinoid molecules in industrial microorganisms, together with microalgae, a single-cell plant suspended in liquid.

Before Renew’s platform, reaching molecular purity with out contamination from THC which may impart psychoactivity or different undesirable penalties was virtually unattainable.

Renew additionally brings to the collaboration dominating mental property and distinctive experience. The firm has been assigned or has licenses for greater than 110 issued patents to supply cannabinoids in microalgae. Microalgae was earlier cultivated at large scale within the context of the biofuel business. Michael Mendez, Renew’s CEO and co-founder, led the microalgae biofuel effort as co-founder of Sapphire Energy.

At Renew, cannabinoid manufacturing follows pharmaceutical business accepted practices at unprecedented scale, underneath strict controls with out the carbon footprint attributable to agriculturally-grown Cannabis vegetation.

Renew additionally introduced the appointment of Gill Chair Dr. Ken Mackie as a member of Renew’s Scientific Advisory Board, efficient instantly.

“Dr. Mackie and the Gill Center are world famend for his or her understanding of the endocannabinoid system. They convey a stage of sophistication and demanding scientific pondering to this area, permitting us to go from cell-based screening to preclinical fashions, all underneath one partnership,” mentioned Mendez.

“Together we are going to convey cannabinoids as API’s (energetic pharmaceutical components) to the forefront of human therapeutics. We count on this work to finally result in vital enhancements in human well being, which is our firm’s most vital objective,” Mendez continued.

“Our artificial biology platform will be capable of produce any of the (at least) 144 recognized cannabinoids in portions and purity that Cannabis vegetation can not produce. This represents a daring step in shifting these molecules past the vegetation and into human scientific trials. The Gill Center’s capability to check the efficacy of those pure and novel molecules throughout a variety of cell-based and preclinical fashions is actually unprecedented.”

Dr. Mackie mentioned: “I couldn’t be extra excited to work with an artificial biology firm like Renew as a result of they’ll ship standard and novel cannabinoid molecules in quantities and purity for potential human therapeutics in a totally new and modern approach. Renew is opening up a complete new pipeline of API’s for drug discovery that may work together with the endocannabinoid system. The cannabinoid area because it pertains to massive pharma has been plagued for many years by the stigma surrounding marijuana vegetation and different synthetics, however now, for the primary time in a GMP (good manufacturing practices) surroundings, we will use the pure and novel molecules that Renew will provide to discover the probabilities for a complete new class of medicines that I’m sure will profit human well being.”

“I’m honored to not solely work with Renew in my capability as a Gill Chair, but in addition to affix their Scientific Advisory Board, the place I hope to convey my specific experience to this distinctive firm. I’m thrilled to work with Dr. Joe Noel, of the Salk Institute for Biological Studies, and Dr. Mike Burkart of University of California San Diego, each co-founders and SAB members of Renew,” Dr. Mackie continued.

About Renew:

Renew Biopharma (www.RenewBiopharma.com) is a Delaware C Corporation based mostly in San Diego, California, centered on making a pipeline of 100 p.c pure, uncontaminated and non-psychoactive cannabinoids in portions giant sufficient to allow human therapeutic breakthroughs and enhance human well being globally. As a artificial biology firm, Renew depends on molecular biology and pathway engineering as an alternative of utilizing agriculturally-grown, energy-intensive Cannabis vegetation. (Plants merely can not produce lots of the most fascinating cannabinoids in adequate portions, nor can they produce cost-efficient cannabinoids freed from undesirable contaminants – from psychoactive THC to pesticides, molds, micro organism and different pathogens.) While Renew’s focus is strictly on human well being, the legalization of medical and leisure Cannabis (the unique supply of cannabinoid molecules) throughout the United States (and shortly in Canada) has prompted a seismic shift in curiosity and acceptance. Renew is poised to unlock a multi-billion-dollar pharmaceutical sector based mostly on a proprietary household of pharmacological chemical compounds – cannabinoids – particularly beginning with pure types of CBG (cannabigerol) and CBD (cannabidiol) and later together with many novel cannabinoids which are potential breakthrough molecules which have beforehand proven promise as human therapeutics. Renew’s mental property portfolio is the results of greater than a decade of educational and private-sector analysis for industrial functions. Renew has unique entry to novel instruments for artificial biology and genetic engineering of microorganisms for the manufacturing of pure and novel cannabinoids at industrial scale. Renew’s dominating IP on this area consists of each particular genes within the biosynthesis of cannabinoids and the flexibility to engineer an artificial cannabinoid pathway into microorganisms, together with microalgae. The cannabinoid pathway has advanced for hundreds of thousands of years within the Cannabis plant, and one of the best ways to precise this pathway outdoors of the Cannabis plant is in one other plant, resembling microalgae, a single-cell liquid plant.

About The Gill Center for Biomolecular Science at Indiana University Bloomington and Professor Mackie:

The Gill Center was established to advance the understanding of advanced organic processes and to coach the next-generation of neuroscientists. It consists of 5 Gill Chairs and their analysis labs. A specific focus of Dr. Mackie’s workforce within the Gill Center are cannabinoid receptors, the mobile receptors liable for most of the psychoactive and therapeutic actions of Cannabis. His group makes use of quite a lot of strategies, together with electrophysiological, molecular biology, immunological, and imaging, to higher perceive how cannabinoid receptors sign and the way their signaling interacts with different mobile processes. Much of the present work in his lab facilities on how phytocannabinoids work together with cannabinoid receptors, such because the capability of cannabidiol (CBD) to counteract the detrimental neurodevelopmental penalties of THC. His workforce is deeply concerned in pre-clinical and scientific drug discovery as cannabinoids have an impact on processes as numerous as reminiscence, analgesia, anxiousness, schizophrenia, and weight problems. The few phytocannabinoids which have been studied thus far (primarily THC and CBD) have demonstrated growing success in no much less than 50 ongoing scientific trials internationally.

Forward-looking Statements:

This press launch comprises “forward-looking statements” that contain substantial dangers and uncertainties for functions of the protected harbor offered by the Private Securities Litigation Reform Act of 1995. All included statements, aside from statements of historic info, relating to technique, future operations, prospects, plans and aims of administration are forward-looking statements. In some circumstances, you possibly can determine these statements by forward-looking phrases resembling “could,” “will,” “proceed,” “anticipate,” “intend,” “may,” “undertaking,” “search,” “count on” or the detrimental or plural of those phrases or comparable expressions. Examples of such statements embrace, however should not restricted to, statements relating as to whether the actions of the corporate outcome in potential therapeutics, our capability to make use of or increase our expertise platforms, our capability to determine and construct a pipeline of product candidates, measurement of market, our capability to acquire and adequately shield mental property rights. Forward-looking statements should not ensures of future efficiency and are topic to dangers and uncertainties that would trigger precise outcomes and occasions to vary materially from these anticipated. You shouldn’t place undue reliance on these forward-looking statements. Such statements are based mostly on administration’s present expectations and contain dangers and uncertainties. Actual outcomes and efficiency may differ materially from these projected within the forward-looking statements on account of many components. Except as in any other case required by legislation, all events disclaim any intention or obligation to replace or revise any forward-looking statements, which communicate solely as of the date they had been made, whether or not on account of new data, future occasions or circumstances or in any other case.

Renew Biopharma Inc.
Larry Shushan, 510-701-6920
larryshushan@renewbiopharma.com
https://RenewBiopharma.com
@RenewBiopharma
or
Indiana University Bloomington
Kevin Fryling, 812-856-2988
kfryling@iu.edu
http://information.iu.edu
@IUNewsroom

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